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The pathophysiology of bilateral and multifocal Wilms tumors: What we can learn from the study of predisposition syndromes.

Pediatric blood & cancer - 1 May 2023

Welter Nils, Brzezinski Jack, Treece Amy, Chintagumpala Murali, Young Matthew D, Perotti Daniela, Kieran Kathleen, Jongmans Marjolijn C J, Murphy Andrew J

Abstract excerpt

Approximately 5% of patients with Wilms tumor present with synchronous bilateral disease. The development of synchronous bilateral Wilms tumor (BWT) is highly suggestive of a genetic or epigenetic predisposition. Patients with known germline predisposition to Wilms tumor (WT1 variants, Beckwith Wiedemann spectrum, TRIM28 variants) have a higher incidence of BWT. This Children's Oncology Group (COG)-International...

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PMID: 36094328
DOI: 10.1002/pbc.29984

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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