Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The O-GlcNAc cycling in neurodevelopment and associated diseases.

Biochemical Society transactions - 16 Dec 2022

Wenzel Dawn M, Olivier-Van Stichelen Stephanie

Abstract excerpt

Proper neuronal development is essential to growth and adult brain function. Alterations at any step of this highly organized sequence of events, due to genetic mutations or environmental factors, triggers brain malformations, which are leading causes of diseases including epilepsy, intellectual disabilities, and many others. The role of glycosylation in neuronal development has been emphasized for many years,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylglucosamine
Share to Glycosylation
Share to Intellectual Disability

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to N-Acetylglucosaminyltransferases

Share to Protein Processing, Post-Translational

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 36383066
DOI: 10.1042/BST20220539
PMCID: PMC10462390

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The O-GlcNAc cycling in neurodevelopment and associated diseases.PMID 36383066Read ↗

Brain O-GlcNAcylation: From Molecular Mechanisms to Clinical Phenotype.Semantic proximity Read ↗

Neurological Aspects of Human Glycosylation DisordersSemantic proximity Read ↗

Glycosylation and behavioral symptoms in neurological disordersSemantic proximity Read ↗

O-GlcNAc transferase congenital disorder of glycosylation (OGT-CDG): Potential mechanistic targets revealed by evaluating the OGT interactome.Semantic proximity Read ↗

The restricted nature of protein glycosylation in the mammalian brainSemantic proximity Read ↗

Neurodevelopmental defects in a mouse model of O-GlcNAc transferase intellectual disabilitySemantic proximity Read ↗

O-GalNAc glycans enrich in white matter tracts and regulate nodes of RanvierSemantic proximity Read ↗

Neurodevelopmental defects in a mouse model of O-GlcNAc transferase intellectual disability.Semantic proximity Read ↗

Neuronal loss of <i>Galnt2</i> Impairs O-glycosylation and Leads to Neurobehavioral Deficits Mimicking GALNT2-CDGSemantic proximity Read ↗

Neurology of inherited glycosylation disorders.Semantic proximity Read ↗

Intellectual disability-associated disruption of O-GlcNAcylation impairs neuronal development and cognitive function in <i>Drosophila</i>Semantic proximity Read ↗

Genetic rescue of pathogenic O-GlcNAc dyshomeostasis associated with microcephaly and motor deficitsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.