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Article

Brain O-GlcNAcylation: From Molecular Mechanisms to Clinical Phenotype.

Advances in neurobiology - 1 Jan 2023

Uygar Batuhan, Lagerlöf Olof

Abstract excerpt

O-GlcNAc is the attachment of β-N-acetylglucosamine to the hydroxyl group of serine and threonine in nuclear and cytoplasmic proteins. It is generally not further elongated but exists as a monosaccharide that can be rapidly added or removed. Thousands of proteins involved in gene transcription, protein translation and degradation as well as the regulation of signal transduction contain O-GlcNAc. Brain is one of...

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PMID: 36255678
DOI: 10.1007/978-3-031-12390-0_9

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