Beyond inflammation: what drives the self-perpetuating cycle of fibrosis in IBD?

Abstract excerpt

Intestinal fibrosis is a major complication of inflammatory bowel disease (IBD). While inflammation is a prerequisite for initiating fibrosis, it does not fully explain its progression, which often continues despite effective anti-inflammatory treatment. This suggests that fibrotic mechanisms evolve from an inflammation-dependent priming phase to a self-perpetuating phase that can operate independently of ongoing...

Topics

• Humans
• Fibrosis
• Inflammatory Bowel Diseases
• Inflammation
• Extracellular Matrix
• Disease Progression
• Animals