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Article

Metabolic network analysis of Crohn's disease reveals sex- and age-specific cellular phenotypes.

Cell systems - 19 Nov 2025

Moore Connor J, Batavia Mariska, Shao William, Zulqarnain Fatima, Kolling Glynis L, Greene Adam, Matthews Jason D, Syed Sana, Papin Jason A

Abstract excerpt

Crohn's disease (CD) is an inflammatory gastrointestinal disease affecting approximately 1 in 1,000 people in North America. Incidence of pediatric CD has been rising in recent decades, and this group is especially at risk of more severe disease development because of the association of CD with developmental deficits. Genome-scale metabolic models (GEMs) present an opportunity to investigate systems-level changes...

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PMID: 41265399
DOI: 10.1016/j.cels.2025.101447
PMCID: PMC12638042

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GEM

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