Article
Synergistic function of Kras mutation and HBx in initiation and progression of hepatocellular carcinoma in mice.
Oncogene - 23 Oct 2014
Ye H, Zhang C, Wang B-J, Tan X-H, Zhang W-P, Teng Y, Yang X
Abstract excerpt
Although the activation of Ras pathway is frequently observed in human hepatocellular carcinoma (HCC), the in vivo role of Ras activation in HCC initiation and progression is underdetermined. To test the consequence of Kras activation in hepatocyte, we generated a hepatocyte-specific Kras(G12D) transgenic mouse strain and observed spontaneous development of HCC in these mice. Remarkably, HBV X protein (HBx)...
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