Article

Multi‑omics factor analysis reveals a RAS mutant-like metabolically distinct AML subgroup resistant to venetoclax

2026-06-16

Abstract excerpt

<title>Abstract</title> <p> Acute myeloid leukemia (AML) exhibits extensive clonal and functional heterogeneity, limiting the ability of current genotype-based classifications to predict treatment response. We applied multi-omics factor analysis (MOFA) in a cohort of AML cases, integrating mutational status, proteomics, metabolomics, and two <italic>ex vivo</italic> drug screens comprising 115 agents targeting...

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Literature Corpus work: 3b8d3f5c-4185-59da-8f3a-43cc5e377ba8
DOI: 10.21203/rs.3.rs-9859908/v1

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