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Single-cell landscape of innate and acquired drug resistance in acute myeloid leukemia

30 Oct 2024

Abstract excerpt

Deep single-cell multi-omic profiling offers a promising approach to understand and overcome drug resistance in relapsed or refractory (rr) acute myeloid leukemia (AML). Here, we combine single-cell ex vivo drug profiling (pharmacoscopy) with single-cell and bulk DNA, RNA, and protein analyses, alongside clinical data from 21 rrAML patients. Unsupervised data integration reveals reduced ex vivo response to the...

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Acute Myeloid Leukemia Research
Immune cells in cancer
Single-cell and spatial transcriptomics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39477946
DOI: 10.1038/s41467-024-53535-4

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