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STAT5b deficiency: lessons from STAT5b gene mutations.

Best practice & research. Clinical endocrinology & metabolism - 1 Feb 2011

Hwa Vivian, Nadeau Kari, Wit Jan M, Rosenfeld Ron G

Abstract excerpt

Growth hormone (GH) regulates insulin-like growth factor (IGF)-I production primarily through activation of the GH receptor (GHR)-signal transducer and activator of transcription (STAT)-5b signaling cascade. One of four STAT proteins (STAT1, -3, -5a and -5b) activated by the GH-GHR system, the critical importance of STAT5b in IGF-I production became evident with the identification of homozygous, autosomal...

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Growth Disorders
Immunologic Deficiency Syndromes
Insulin-Like Growth Factor I
Janus Kinase 2
Signal Transduction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

STAT5 Transcription Factor

T-Lymphocytes, Regulatory

Tumor Suppressor Proteins

Source

Identifiers

PMID: 21396575
DOI: 10.1016/j.beem.2010.09.003

Genes

GHR
STAT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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