Article

Accurate <i>in vivo</i> population sequencing uncovers drivers of within-host genetic diversity in viruses

2018-06-18

Abstract excerpt

<h4>ABSTRACT</h4> Mutations fuel evolution and facilitate adaptation to novel environments. However, characterizing the spectrum of mutations in a population is obscured by high error rates of next generation sequencing. Here, we present AccuNGS, a novel in vivo sequencing approach that detects variants as rare as 1:10,000. Applying it to 46 clinical samples taken from early infections of the human-infecting vir...

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Literature Corpus work: 3b7723c0-416d-5dd7-99f7-a356c89603b8
DOI: 10.1101/349498

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