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Article

Highly sensitive and specific detection of rare variants in mixed viral populations from massively parallel sequence data.

PLoS computational biology - 1 Jan 2012

Macalalad Alexander R, Zody Michael C, Charlebois Patrick, Lennon Niall J, Newman Ruchi M, Malboeuf Christine M, Ryan Elizabeth M, Boutwell Christian L, Power Karen A, Brackney Doug E, Pesko Kendra N, Levin Joshua Z, Ebel Gregory D, Allen Todd M, Birren Bruce W, Henn Matthew R

Abstract excerpt

Viruses diversify over time within hosts, often undercutting the effectiveness of host defenses and therapeutic interventions. To design successful vaccines and therapeutics, it is critical to better understand viral diversification, including comprehensively characterizing the genetic variants in viral intra-host populations and modeling changes from transmission through the course of infection. Massively...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22438797
DOI: 10.1371/journal.pcbi.1002417
PMCID: PMC3305335

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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