Article

<i>Arid1a</i> loss potentiates pancreatic β-cell regeneration through activation of EGF signaling

2020-02-11

Abstract excerpt

<h4>Summary</h4> The dynamic regulation of β-cell abundance is poorly understood. Since chromatin remodeling plays critical roles in liver regeneration, these mechanisms could be generally important for regeneration in other tissues. Here we show that the ARID1A mammalian SWI/SNF complex subunit is a critical regulator of β-cell regeneration. Arid1a is highly expressed in quiescent β-cells but is physiologically...

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Literature Corpus work: 3b60cbc1-9a23-5348-9d78-5daee7717794
DOI: 10.1101/2020.02.10.942615

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