Article
Arid1a mutation suppresses TGF-β signaling and induces cholangiocarcinoma.
Cell reports - 30 Aug 2022
Guo Bing, Friedland Scott C, Alexander William, Myers Jacquelyn A, Wang Wenjia, O'Dell Michael R, Getman Michael, Whitney-Miller Christa L, Agostini-Vulaj Diana, Huber Aaron R, Mello Stephano S, Vertino Paula M, Land Hartmut K, Steiner Laurie A, Hezel Aram F
Abstract excerpt
Activating KRAS mutations and functional loss of members of the SWI/SNF complex, including ARID1A, are found together in the primary liver tumor cholangiocarcinoma (CC). How these mutations cooperate to promote CC has not been established. Using murine models of hepatocyte and biliary-specific lineage tracing, we show that Kras and Arid1a mutations drive the formation of CC and tumor precursors from the biliary...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.