An In Vivo Zebrafish Model for Interrogating ROS‐Mediated Pancreatic β ‐Cell Injury, Response, and Prevention

Abstract excerpt

It is well known that a chronic state of elevated reactive oxygen species (ROS) in pancreatic β ‐cells impairs their ability to release insulin in response to elevated plasma glucose. Moreover, at its extreme, unmitigated ROS drives regulated cell death. This dysfunctional state of ROS buildup can result both from genetic predisposition and environmental factors such as obesity and overnutrition. Importantly,...

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