Nitroreductase-mediated cell ablation uncovers the pivotal role of ependymoglial cells in entire cortex regeneration in axolotls

Abstract excerpt

<title>Abstract</title> <p>Developing precise targeted cell ablation in the axolotl (Ambystoma mexicanum) is crucial for elucidating the roles or interactions of specific cell types in regeneration and modeling diseases. Here we establish a Nitroreductase (NTR)-based inducible cell ablation system in axolotls. Through generation of Sox2:Cherry-NTR knock-in axolotls, we achieve efficient ablation of ependymoglial...

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• Axons
• Chickens
• Fluorescent Dyes
• Gene Expression
• Green Fluorescent Proteins
• Neurons
• Recombinases
• Staining and Labeling

Identifiers and source

Literature Corpus work

44006d0d-b2ac-57b0-8c12-39cef443b154

DOI

10.21203/rs.3.rs-6585454/v1