Article
Conditional targeted cell ablation in zebrafish: a new tool for regeneration studies.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Apr 2007
Curado Silvia, Anderson Ryan M, Jungblut Benno, Mumm Jeff, Schroeter Eric, Stainier Didier Y R
Abstract excerpt
Conditional targeted cell ablation in zebrafish would greatly expand the utility of this genetic model system in developmental and regeneration studies, given its extensive regenerative capabilities. Here, we show that, by combining chemical and genetic tools, one can ablate cells in a temporal- and spatial-specific manner in zebrafish larvae. For this purpose, we used the bacterial Nitroreductase (NTR) enzyme to...
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