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Retinal Toxicity, in vivo and in vitro, Associated with Inhibition of Nicotinamide Phosphoribosyltransferase

11 Dec 2014

Abstract excerpt

Nicotinamide phosphoribosyltransferase (NAMPT) is a pleiotropic protein with intra- and extra-cellular functions as an enzyme, cytokine, growth factor, and hormone. NAMPT is of interest for oncology, because it catalyzes the rate-limiting step in the salvage pathway to generate nicotinamide adenine dinucleotide (NAD), which is considered a universal energy- and signal-carrying molecule involved in cellular energy...

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PMID: 25505128
DOI: 10.1093/toxsci/kfu268

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Retinal Toxicity, in vivo and in vitro, Associated with Inhibition of Nicotinamide PhosphoribosyltransferasePMID 25505128Read ↗

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