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Article

A paradoxical population structure of var DBLα types in Africa.

PLoS pathogens - 1 Feb 2025

Tan Mun Hua, Tiedje Kathryn E, Feng Qian, Zhan Qi, Pascual Mercedes, Shim Heejung, Chan Yao-Ban, Day Karen P

Abstract excerpt

The var multigene family encodes Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), central to host-parasite interactions. Genome structure studies have identified three major groups of var genes by specific upstream sequences (upsA, B, or C). Var with these ups groups have different chromosomal locations, transcriptional directions, and associations with disease severity. Here we explore temporal and...

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Topics

Plasmodium falciparum
Protozoan Proteins
Humans
Malaria, Falciparum
Ghana
Africa
Genetic Variation

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Identifiers

PMID: 39903780
DOI: 10.1371/journal.ppat.1012813
PMCID: PMC11793742

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