Article
Drosophila Toxicogenomics: genetic variation and sexual dimorphism in susceptibility to 4-Methylimidazole.
Human genomics - 4 Nov 2024
Collins Katelynne M, Howansky Elisabeth, Macon-Foley Sarah C, Adonay Maria E, Shankar Vijay, Lyman Richard F, Nazario-Yepiz Nestor Octavio, Brooks Jordyn K, Lyman Rachel A, Mackay Trudy F C, Anholt Robert R H
Abstract excerpt
BACKGROUND: 4-methylimidazole is a ubiquitous and potentially carcinogenic environmental toxicant. Genetic factors that contribute to variation in susceptibility to its toxic effects are challenging to assess in human populations. We used the Drosophila melanogaster Genetic Reference Panel (DGRP), a living library of natural genetic variation, to identify genes with human orthologs associated with variation in...
Topics
- Animals
- Female
- Male
- Drosophila melanogaster
- Sex Characteristics
- Imidazoles
- Genetic Variation
- Genome-Wide Association Study
- Toxicogenetics
- Humans
- Gene Regulatory Networks