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Article

Therapy-associated remodeling of pancreatic cancer revealed by single-cell spatial transcriptomics and optimal transport analysis

2023-06-29

Abstract excerpt

<h4>ABSTRACT</h4> In combination with cell intrinsic properties, interactions in the tumor microenvironment modulate therapeutic response. We leveraged high-plex single-cell spatial transcriptomics to dissect the remodeling of multicellular neighborhoods and cell–cell interactions in human pancreatic cancer associated with specific malignant subtypes and neoadjuvant chemotherapy/radiotherapy. We developed Spatial...

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Literature Corpus work
3fc0b99b-befd-5d12-8fcc-56b584d0d51f
DOI
10.1101/2023.06.28.546848
Open publication

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Therapy-associated remodeling of pancreatic cancer revealed by single-cell spatial transcriptomics and optimal transport analysisDOI 10.1101/2023.06.28.546848
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