Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HLA-A2 CAR/IL-2-CISC engineered Treg display robust in vitro and in vivo antigen-specific regulatory function

14 Aug 2025

Abstract excerpt

Chimeric antigen (Ag) receptor-expressing T regulatory cells (CAR-Treg) offer therapeutic potential for treating autoimmunity, allograft rejection, and graft-versus-host disease (GvHD). HLA-A∗02 (A2) CAR (A2CAR)-expressing natural Treg have shown efficacy in preclinical models and are being evaluated in phase 1/2 trials. In the current study, we utilized homology-directed-repair (HDR)-based gene editing to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Immune Cell Function and Interaction
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40955314
DOI: 10.1016/j.omtm.2025.101561

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HLA-A2 CAR/IL-2-CISC engineered Treg display robust in vitro and in vivo antigen-specific regulatory functionPMID 40955314Read ↗

Precision engineering of an anti-HLA-A2 chimeric antigen receptor in regulatory T cells for transplant immune toleranceSemantic proximity Read ↗

Chimeric anti-HLA antibody receptor engineered human regulatory T cells suppress alloantigen-specific B cells from pre-sensitized transplant recipientsSemantic proximity Read ↗

HLA-A*02:01-directed chimeric antigen receptor/forkhead box P3-engineered CD4+ T cells adopt a regulatory phenotype and suppress established graft-versus-host disease.Semantic proximity Read ↗

High affinity chimeric antigen receptor signaling induces an inflammatory program in human regulatory T cellsSemantic proximity Read ↗

Unlocking the potential of Tregs: innovations in CAR technologySemantic proximity Read ↗

Systematic testing and specificity mapping of alloantigen-specific chimeric antigen receptors in regulatory T cellsSemantic proximity Read ↗

Functional effects of chimeric antigen receptor co-receptor signaling domains in human TregsSemantic proximity Read ↗

Gene editing of <i>CD3 epsilon</i> gene to redirect regulatory T cells for adoptive T cell transferSemantic proximity Read ↗

Gene editing to induce FOXP3 expression in human CD4+ T cells leads to a stable regulatory phenotype and function.Semantic proximity Read ↗

A differentiated and durable allogeneic strategy applicable to cell therapiesSemantic proximity Read ↗

Gene editing of CD3 epsilon to redirect regulatory T cells for adoptive T cell transferSemantic proximity Read ↗

Chimeric antigen receptor-modified human regulatory T cells that constitutively express IL-10 maintain their phenotype and are potently suppressive.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.