Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CAR- and TRuC-redirected regulatory T cells differ in capacity to control adaptive immunity to FVIII.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Sept 2021

Rana Jyoti, Perry Daniel J, Kumar Sandeep R P, Muñoz-Melero Maite, Saboungi Rania, Brusko Todd M, Biswas Moanaro

Abstract excerpt

Regulatory T cells (Tregs) control immune responses in autoimmune disease, transplantation, and enable antigen-specific tolerance induction in protein-replacement therapies. Tregs can exert a broad array of suppressive functions through their T cell receptor (TCR) in a tissue-directed and antigen-specific manner. This capacity can now be harnessed for tolerance induction by "redirecting" polyclonal Tregs to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptive Immunity
Share to CD28 Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD3 Complex

Share to Factor VIII

Share to Hemophilia A

Share to Interleukin-10

Share to Receptors, Chimeric Antigen

Share to T-Lymphocytes, Regulatory

Source

Open in PubMed Open full text

Identifiers

PMID: 33940160
DOI: 10.1016/j.ymthe.2021.04.034
PMCID: PMC8417451

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CAR- and TRuC-redirected regulatory T cells differ in capacity to control adaptive immunity to FVIII.PMID 33940160Read ↗

FVIII-specific human chimeric antigen receptor T-regulatory cells suppress T- and B-cell responses to FVIIISemantic proximity Read ↗

Unlocking the potential of Tregs: innovations in CAR technologySemantic proximity Read ↗

High affinity chimeric antigen receptor signaling induces an inflammatory program in human regulatory T cellsSemantic proximity Read ↗

Gene editing of CD3 epsilon to redirect regulatory T cells for adoptive T cell transferSemantic proximity Read ↗

Gene editing of <i>CD3 epsilon</i> gene to redirect regulatory T cells for adoptive T cell transferSemantic proximity Read ↗

Allogeneic CAR-T Cells: Engineering Around Host ImmunitySemantic proximity Read ↗

TCR affinity and specificity requirements for human regulatory T-cell functionSemantic proximity Read ↗

A narrow T cell receptor repertoire instructs thymic differentiation of MHC class Ib–restricted CD8+ regulatory T cellsSemantic proximity Read ↗

Functional effects of chimeric antigen receptor co-receptor signaling domains in human TregsSemantic proximity Read ↗

Human Antigen-Specific Regulatory T Cells Generated by T Cell Receptor Gene TransferSemantic proximity Read ↗

T-cell responses over time in a mild hemophilia A inhibitor subject: epitope identification and transient immunogenicity of the corresponding self-peptide.Semantic proximity Read ↗

Chimeric anti-HLA antibody receptor engineered human regulatory T cells suppress alloantigen-specific B cells from pre-sensitized transplant recipientsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.