Article

Stanniocalcin 2 (STC2) is a potent biomarker of hepatocellular carcinoma with its expression being augmented in Nrf1α-deficient cells, but diminished in Nrf2-deficient cells

2023-05-18

Abstract excerpt

For insights into the fact that liver-specific knockout of Nrf1 leads to development of non-alcoholic steatohepatitis and spontaneous hepatoma, we previously found that loss of Nrf1α (i.e., a full-length isoform encoded by Nfe2l1 ) promotes HepG2-derived tumor growth in xenograft mice, but malgrowth of the xenograft tumor is significantly suppressed by knockout of Nrf2 (encoded by Nfe2l2 ). The mechanism underly...

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Literature Corpus work: 3b0930e9-0a3a-5bff-a76d-635115f6c815
DOI: 10.1101/2023.05.15.540796

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