Article
Molecular Mechanisms Underlying Hepatocellular Carcinoma Induction by Aberrant NRF2 Activation-Mediated Transcription Networks: Interaction of NRF2-KEAP1 Controls the Fate of Hepatocarcinogenesis.
International journal of molecular sciences - 29 Jul 2020
Haque Effi, Karim M Rezaul, Salam Teeli Aamir, Śmiech Magdalena, Leszczynski Paweł, Winiarczyk Dawid, Parvanov Emil D, Atanasov Atanas G, Taniguchi Hiroaki
Abstract excerpt
NF-E2-related factor 2 (NRF2) is a basic leucine zipper transcription factor, a master regulator of redox homeostasis regulating a variety of genes for antioxidant and detoxification enzymes. NRF2 was, therefore, initially thought to protect the liver from oxidative stress. Recent studies, however, have revealed that mutations in NRF2 cause aberrant accumulation of NRF2 in the nucleus and exert the upregulation...
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