Article

Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease

2023-05-28

Abstract excerpt

<h4>ABSTRACT</h4> Population level variation and molecular mechanisms behind insulin secretion in response to carbohydrate, protein, and fat remain uncharacterized despite ramifications for personalized nutrition. Here, we define prototypical insulin secretion dynamics in response to the three macronutrients in islets from 140 cadaveric donors, including those diagnosed with type 2 diabetes. While islets from the...

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Literature Corpus work: 3b08f532-94ea-5c36-a227-1b1215a32868
DOI: 10.1101/2023.05.24.23290298

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