Size-Modulated Mesoderm-Endoderm Divergence and Myocardial Cavitation in Micropatterned Cardioids

Abstract excerpt

<h4>ABSTRACT</h4> The human heart, originating from the splanchnic mesoderm, is the first functional organ to develop, co-evolving with the foregut endoderm through reciprocal signaling. Previously, cardioid models offered new insights on cardiovascular cell lineages and tissue morphogenesis during heart development, while mesoderm-endoderm crosstalk remain incompletely understood. Here, we integrated micropatter...

Topics

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• Congenital heart defects research
• Congenital Heart Disease Studies
• Heart Defects, Congenital
• Mutation
• Protein Kinase Inhibitors
• Protein Tyrosine Phosphatase, Non-Receptor Type 11
• rho-Associated Kinases
• Tissue Engineering and Regenerative Medicine

Identifiers and source

Literature Corpus work

3b01826b-7cac-5c0c-b165-39aebd7bfb02

DOI

10.1101/2025.09.17.676874