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Alliance of Heart and Endoderm: Multilineage Organoids to Model Co-development

16 Feb 2023

Abstract excerpt

Studies in animal models tracing organogenesis of the mesoderm-derived heart have emphasized the importance of signals coming from adjacent endodermal tissues in coordinating proper cardiac morphogenesis. Although in vitro models such as cardiac organoids have shown great potential to recapitulate the physiology of the human heart, they are unable to capture the complex crosstalk that takes place between the...

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PMID: 36795851
DOI: 10.1161/circresaha.122.321769

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