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Human heart-forming organoids recapitulate early heart and foregut development

8 Feb 2021

Abstract excerpt

Organoid models of early tissue development have been produced for the intestine, brain, kidney and other organs, but similar approaches for the heart have been lacking. Here we generate complex, highly structured, three-dimensional heart-forming organoids (HFOs) by embedding human pluripotent stem cell aggregates in Matrigel followed by directed cardiac differentiation via biphasic WNT pathway modulation with...

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PMID: 33558697
DOI: 10.1038/s41587-021-00815-9

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