Article

A chronic signaling TGFb zebrafish reporter identifies immune response in melanoma

2022-09-30

Abstract excerpt

Developmental signaling pathways associated with growth factors such as TGFb are commonly dysregulated in melanoma. Here we identified a human TGFb enhancer specifically activated in melanoma cells treated with TGFB1 ligand. We generated stable transgenic zebrafish with this TGFb Induced Enhancer driving green fluorescent protein ( TIE:EGFP ). TIE:EGFP was not expressed in normal melanocytes or early melanomas b...

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Identifiers and source

Literature Corpus work: 954a5451-cce3-529e-a346-9c034f6397ed
DOI: 10.1101/2022.09.29.510035

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