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Article

TNFSF15 facilitates differentiation and polarization of macrophages toward M1 phenotype to inhibit tumor growth.

Oncoimmunology - 1 Jan 2022

Zhao Can-Can, Han Qiu-Ju, Ying Hao-Yan, Gu Xiang-Xiang, Yang Na, Li Lu-Yuan, Zhang Qiang-Zhe

Abstract excerpt

Macrophages of the M2 phenotype in malignant tumors significantly aid tumor progression and metastasis, as opposed to the M1 phenotype that exhibits anti-cancer characteristics. Raising the ratio of M1/M2 is thus a promising strategy to ameliorate the tumor immunomicroenvironment toward cancer inhibition. We report here that tumor necrosis factor superfamily-15 (TNFSF15), a cytokine with anti-angiogenic...

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Identifiers

PMID: 35127254
DOI: 10.1080/2162402X.2022.2032918
PMCID: PMC8812784

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