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Article

Sex-Dependent Differences in Spontaneous Autoimmunity in Adult 3xTg-AD Mice.

Journal of Alzheimer's disease : JAD - 1 Jan 2018

Kapadia Minesh, Mian M Firoz, Michalski Bernadeta, Azam Amber B, Ma Donglai, Salwierz Patrick, Christopher Adam, Rosa Elyse, Zovkic Iva B, Forsythe Paul, Fahnestock Margaret, Sakic Boris

Abstract excerpt

The triple-transgenic (3xTg-AD) mouse strain is a valuable model of Alzheimer's disease (AD) because it develops both amyloid-β (Aβ) and tau brain pathology. However, 1-year-old 3xTg-AD males no longer show plaques and tangles, yet early in life they exhibit diverse signs of systemic autoimmunity. The current study aimed to address whether females, which exhibit more severe plaque/tangle pathology at 1 year of...

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PMID: 29710702
DOI: 10.3233/JAD-170779

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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