Article

Deep learning insights into the architecture of the mammalian egg-sperm fusion synapse

2023-07-28

Abstract excerpt

A crucial event in sexual reproduction is when haploid sperm and egg fuse to form a new diploid organism at fertilization. In mammals, direct interaction between egg JUNO and sperm IZUMO1 mediates gamete membrane adhesion, yet their role in fusion remains enigmatic. We used AlphaFold to predict the structure of other extracellular proteins essential for fertilization to determine if they could form a complex that...

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Literature Corpus work: 3a3c514e-0df2-5c33-b200-498797cf2cca
DOI: 10.1101/2023.07.27.550195

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