Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A conserved fertilization complex bridges sperm and egg in vertebrates

17 Oct 2024

Abstract excerpt

Fertilization, the basis for sexual reproduction, culminates in the binding and fusion of sperm and egg. Although several proteins are known to be crucial for this process in vertebrates, the molecular mechanisms remain poorly understood. Using an AlphaFold-Multimer screen, we identified the protein Tmem81 as part of a conserved trimeric sperm complex with the essential fertilization factors Izumo1 and Spaca6. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animal Genetics and Reproduction
Share to Genetics, Aging, and Longevity in Model Organisms
Share to Reproductive Biology and Fertility

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39423812
DOI: 10.1016/j.cell.2024.09.035

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A conserved fertilization complex bridges sperm and egg in vertebratesPMID 39423812Read ↗

Molecular architecture of the human sperm IZUMO1 and egg JUNO fertilization complexSemantic proximity Read ↗

The Ly6/uPAR protein Bouncer is necessary and sufficient for species-specific fertilization.Semantic proximity Read ↗

TMEM95 is a sperm membrane protein essential for mammalian fertilizationSemantic proximity Read ↗

Deep learning insights into the architecture of the mammalian egg-sperm fusion synapseSemantic proximity Read ↗

Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization.Semantic proximity Read ↗

Deep learning insights into the architecture of the mammalian egg-sperm fusion synapseSemantic proximity Read ↗

Sperm proteins SOF1, TMEM95, and SPACA6 are required for sperm−oocyte fusion in miceSemantic proximity Read ↗

SPACA6 ectodomain structure reveals a conserved superfamily of gamete fusion-associated proteinsSemantic proximity Read ↗

Sperm-Egg Fusion: A Molecular Enigma of Mammalian ReproductionSemantic proximity Read ↗

Sperm-Egg InteractionSemantic proximity Read ↗

1700029I15Rik orchestrates the biosynthesis of acrosomal membrane proteins required for sperm–egg interactionSemantic proximity Read ↗

The mechanism of sperm–egg interaction and the involvement of IZUMO1 in fusionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.