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Article

Genome editing to define the function of risk loci and variants in rheumatic disease.

Nature reviews. Rheumatology - 1 Aug 2021

Baglaenko Yuriy, Macfarlane Dana, Marson Alexander, Nigrovic Peter A, Raychaudhuri Soumya

Abstract excerpt

Discoveries in human genetic studies have revolutionized our understanding of complex rheumatic and autoimmune diseases, including the identification of hundreds of genetic loci and single nucleotide polymorphisms that potentially predispose individuals to disease. However, in most cases, the exact disease-causing variants and their mechanisms of action remain unresolved. Functional follow-up of these findings is...

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Identifiers

PMID: 34188205
DOI: 10.1038/s41584-021-00637-8
PMCID: PMC10782829

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