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kir-mapper: A Toolkit for Killer-Cell Immunoglobulin-Like Receptor (KIR) Genotyping From Short-Read Second-Generation Sequencing Data.

HLA - 1 Mar 2025

Castelli Erick C, Pereira Raphaela Neto, Paes Gabriela Sato, Andrade Heloisa S, Ferreira Marcel Rodrigues, de Freitas Santos Ícaro Scalisse, Vince Nicolas, Pollock Nicholas R, Norman Paul J, Meyer Diogo

Abstract excerpt

Killer cell immunoglobulin-like receptors (KIRs) regulate natural killer (NK) cell responses by activating or inhibiting their functions. Genotyping KIR genes from short-read second-generation sequencing data remains challenging as cross-alignments among genes and alignment failure arise from gene similarities and extreme polymorphism. Several bioinformatics pipelines and programs, including PING and T1K, have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Killer Cells, Natural

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Source

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Identifiers

PMID: 40095784
DOI: 10.1111/tan.70092
PMCID: PMC11927768

Genes

KIR3DL2
KIR3DL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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