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Nicotinamide Mononucleotide Restores Pancreatic β-Cell Function in Type 2 Diabetes through SIRT6-HIF-1α-Mediated Mitochondrial Stress Adaptation and Glycolytic Reprogramming

2026-08-28

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<title>Abstract</title> <p>Type 2 diabetes mellitus (T2DM) is characterized by progressive pancreatic β-cell dysfunction, in which mitochondrial impairment represents a central pathogenic event. However, effective strategies to restore mitochondrial resilience and preserve β-cell function remain limited. Nicotinamide mononucleotide (NMN), a precursor of NAD⁺, has emerged as a metabolic intervention capable of imp...

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Literature Corpus work: 39f6d8f6-04d6-5ca1-bb0a-aef580ce158e
DOI: 10.21203/rs.3.rs-10560703/v1

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Nicotinamide Mononucleotide Restores Pancreatic β-Cell Function in Type 2 Diabetes through SIRT6-HIF-1α-Mediated Mitochondrial Stress Adaptation and Glycolytic ReprogrammingDOI 10.21203/rs.3.rs-10560703/v1Read

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