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Article

Hypermethylation of Hepatic Mitochondrial ND6 Provokes Systemic Insulin Resistance

2 May 2021

Abstract excerpt

Abstract Mitochondrial epigenetics is rising as intriguing notion for its potential involvement in aging and diseases, while the details remain largely unexplored. Here it is shown that among the 13 mitochondrial DNA (mtDNA) encoded genes, NADH‐dehydrogenase 6 (ND6) transcript is primarily decreased in obese and type 2 diabetes populations, which negatively correlates with its distinctive hypermethylation....

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Share to Epigenetics and DNA Methylation
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PMID: 34141522
DOI: 10.1002/advs.202004507

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