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Article

Association of the human urate transporter 1 with reduced renal uric acid excretion and hyperuricemia in a German Caucasian population

29 Dec 2005

Abstract excerpt

OBJECTIVE: Human urate transporter 1 (hURAT1) is a member of the organic anion transporter family (SLC22A12) that mainly regulates tubular urate reabsorption. Loss-of-function mutations result in idiopathic hypouricemia. The present case-control study was designed to analyze whether hURAT1 might also be a candidate gene for hyperuricemia with primary reduced renal urate excretion. METHODS: DNA samples from 389...

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PMID: 16385546
DOI: 10.1002/art.21499

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