Article
[Urate transporter and renal hypouricemia].
Rinsho byori. The Japanese journal of clinical pathology - 1 Sept 2003
Enomoto Atsushi, Niwa Thosimitsu, Kanai Yoshikatsu, Endou Hitoshi
Abstract excerpt
Urate, a purine metabolite, is a cause of gout(hyperuricemia), which is an independent risk factor for cardiovascular disease. Urate is a scavenger of reactive oxygen radicals that are involved in numerous diseases. Because humans have a renal urate reabsorption system and have lost hepatic uricase by mutational silencing in evolution, urate is present in human blood at high levels. We identified the...
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