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Article

Glucocerebrosidase is imported into mitochondria and preserves complex I integrity and energy metabolism.

Nature communications - 6 Apr 2023

Baden Pascale, Perez Maria Jose, Raji Hariam, Bertoli Federico, Kalb Stefanie, Illescas María, Spanos Fokion, Giuliano Claudio, Calogero Alessandra Maria, Oldrati Marvin, Hebestreit Hannah, Cappelletti Graziella, Brockmann Kathrin, Gasser Thomas, Schapira Anthony H V, Ugalde Cristina, Deleidi Michela

Abstract excerpt

Mutations in GBA1, the gene encoding the lysosomal enzyme β-glucocerebrosidase (GCase), which cause Gaucher's disease, are the most frequent genetic risk factor for Parkinson's disease (PD). Here, we employ global proteomic and single-cell genomic approaches in stable cell lines as well as induced pluripotent stem cell (iPSC)-derived neurons and midbrain organoids to dissect the mechanisms underlying...

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Source

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Identifiers

PMID: 37024507
DOI: 10.1038/s41467-023-37454-4
PMCID: PMC10079970

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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