Article

Lysosomal perturbations in dopaminergic neurons derived from induced pluripotent stem cells with <i>PARK2</i> mutation

2019-08-13

Abstract excerpt

Mutations in the PARK2 gene encoding parkin, an E3 ubiquitin ligase, are associated with autosomal recessive early-onset Parkinson’s disease (PD). While parkin has been implicated in the regulation of mitophagy and proteasomal degradation, the precise mechanism leading to neurodegeneration in both sporadic and familial PD upon parkin loss-of-function mutations remains unknown. Cultures of isogenic induced pluripo...

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Literature Corpus work: 3a8dcb92-f6ad-5819-b393-63428e8235b4
DOI: 10.1101/734244

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