Article

Glucocerebrosidase, a Parkinson´s disease-associated protein, is imported into mitochondria and regulates complex I assembly and function

2022-05-02

Abstract excerpt

<title>Abstract</title> <p>Mutations in the lysosomal enzyme β-glucocerebrosidase (GCase), which cause Gaucher's disease, are the most frequent genetic risk factor for Parkinson’s disease (PD). Here, we employed global proteomic and single-cell genomic approaches in stable cell lines as well as induced pluripotent stem cell (iPSC)-derived neurons and midbrain organoids to dissect the mechanisms underlying GCase-r...

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Literature Corpus work: 8d03dc5b-800d-56d6-9a69-d94b3f3a8781
DOI: 10.21203/rs.3.rs-1521848/v1

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