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Targeting lysosomal pH restores mitochondrial quality control in GBA1-mutant Parkinson's disease.

Translational neurodegeneration - 17 Jun 2026

Sheshadri Preethi, Costa-Besada Maria Alicia, Fisher Alessia, Kiraly Szilvia, Singh Kritarth, Kourouzidou Ioanna, Blacker Thomas S, Zeng Jialiu, Shirihai Orian S, Grinstaff Mark W, Duchen Michael R

Abstract excerpt

BACKGROUND: Heterozygous mutations in the glucocerebrosidase gene (GBA1), which encodes the lysosomal enzyme β-glucocerebrosidase (GCase), are a genetic risk factor for Parkinson's disease (PD). The pathophysiological consequences of GBA1 mutations on dopaminergic neuronal function, especially their impact on lysosomal function, mitophagy, and mitochondrial bioenergetics, remain unclear. METHODS: Fibroblasts and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42310725
DOI: 10.1186/s40035-026-00559-z
PMCID: PMC13277009

Genes

GBA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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