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Article

Lysosomal Pathogenesis of Parkinson's Disease: Insights From LRRK2 and GBA1 Rodent Models.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics - 1 Jan 2023

Volta Mattia

Abstract excerpt

The discovery of mutations in LRRK2 and GBA1 that are linked to Parkinson's disease provided further evidence that autophagy and lysosome pathways are likely implicated in the pathogenic process. Their protein products are important regulators of lysosome function. LRRK2 has kinase-dependent effects on lysosome activity, autophagic efficacy and lysosomal Ca2+ signaling. Glucocerebrosidase (encoded by GBA1) is a...

Topics

Animals
alpha-Synuclein
Glucosylceramidase
Lysosomes
Mutation
Parkinson Disease
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 36085537
DOI: 10.1007/s13311-022-01290-z
PMCID: PMC10119359

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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