Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms.

doi:10.1073/pnas.1619052114

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Article

Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms.

Proceedings of the National Academy of Sciences of the United States of America - 17 Jan 2017

Guo Michael H, Nandakumar Satish K, Ulirsch Jacob C, Zekavat Seyedeh M, Buenrostro Jason D, Natarajan Pradeep, Salem Rany M, Chiarle Roberto, Mitt Mario, Kals Mart, Pärn Kalle, Fischer Krista, Milani Lili, Mägi Reedik, Palta Priit, Gabriel Stacey B, Metspalu Andres, Lander Eric S, Kathiresan Sekar, Hirschhorn Joel N, Esko Tõnu, Sankaran Vijay G

Abstract excerpt

Genetic variants affecting hematopoiesis can influence commonly measured blood cell traits. To identify factors that affect hematopoiesis, we performed association studies for blood cell traits in the population-based Estonian Biobank using high-coverage whole-genome sequencing (WGS) in 2,284 samples and SNP genotyping in an additional 14,904 samples. Using up to 7,134 samples with available phenotype data, our...

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PMID: 28031487
DOI: 10.1073/pnas.1619052114
PMCID: PMC5255587

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