Article

The conjugation-resistant bile acid norUDCA cures liver fibrosis but impairs systemic energy metabolism

2025-12-10

Abstract excerpt

<title>Abstract</title> <p>Bile acids (BAs) play an important role in systemic metabolic improvements following bariatric surgery. In this study, we found that orally administered norursodeoxycholic acid (norUDCA), a conjugation-resistant C23 derivative of naturally occurring UDCA, accumulated in peripheral organs including heart and brown adipose tissue (BAT). Moreover, norUDCA decreased systemic levels of endog...

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Literature Corpus work: 39cf8608-92de-5822-ad96-6d648055166c
DOI: 10.21203/rs.3.rs-8280795/v1

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