Article

Hepatic insulin resistance is the basis of bile acid dysmetabolism in metabolic dysfunction-associated steatotic liver disease

2025-11-19

Abstract excerpt

<h4>Summary</h4> Bile acids (BAs) are liver-synthesized steroids that facilitate lipid digestion and regulate diverse metabolic pathways. Because of their cytotoxicity, excessive hepatic BA accumulation has been implicated in the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD). Although circulating BAs are frequently elevated in MASLD, it is unclear whether similar alterations occ...

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Literature Corpus work: eb1cbcb9-a378-5723-a361-7af828890545
DOI: 10.1101/2025.11.18.25340381

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