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Comprehensive Clinical and Genetic Analyses of Circulating Bile Acids and Their Associations With Diabetes and Its Indices.

Diabetes - 1 Aug 2024

Choucair Ibrahim, Mallela Deepthi P, Hilser James R, Hartiala Jaana A, Nemet Ina, Gogonea Valentin, Li Lin, Lusis Aldons J, Fischbach Michael A, Tang W H Wilson, Allayee Hooman, Hazen Stanley L

Abstract excerpt

Bile acids (BAs) are cholesterol-derived compounds that regulate glucose, lipid, and energy metabolism. Despite their significance in glucose homeostasis, the association between specific BA molecular species and their synthetic pathways with diabetes is unclear. Here, we used a recently validated, stable-isotope dilution, high-performance liquid chromatography with tandem mass spectrometry method to quantify a...

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Identifiers

PMID: 38701355
DOI: 10.2337/db23-0676
PMCID: PMC11262044

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