Post-genome-wide association study variant-to-function challenges in asthma research.

Abstract excerpt

Genome-wide association studies of asthma have identified nearly 200 independent loci, yet the mechanisms through which individual loci influence asthma risk remain largely unknown. A growing array of computational and experimental tools has begun to fill these gaps by identifying causal variants and effector genes and characterizing their functions. In parallel, emerging studies are exploring the translational...

Topics

• Humans
• Asthma
• Genome-Wide Association Study
• Genetic Predisposition to Disease
• Multiomics
• Genetic Variation