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Article

Mig-6 deficiency cooperates with oncogenic Kras to promote mouse lung tumorigenesis.

Lung cancer (Amsterdam, Netherlands) - 1 Oct 2017

Liu Jian, Cho Sung-Nam, Wu San-Pin, Jin Nili, Moghaddam Seyed Javad, Gilbert Jennifer L, Wistuba Ignacio, DeMayo Francesco J

Abstract excerpt

OBJECTIVES: Lung cancer is the leading cause of cancer related deaths worldwide and mutation activating KRAS is one of the most frequent mutations found in lung adenocarcinoma. Identifying regulators of KRAS may aid in the development of therapies to treat this disease. The mitogen-induced gene 6, MIG-6, is a small adaptor protein modulating signaling in cells to regulate the growth and differentiation in...

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Topics

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Share to Adaptor Proteins, Signal Transducing
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, ras

Share to Hyperplasia

Share to Intracellular Signaling Peptides and Proteins

Share to Kaplan-Meier Estimate

Share to Receptor, ErbB-4

Share to Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 29191600
DOI: 10.1016/j.lungcan.2017.08.001
PMCID: PMC5718380

Genes

KRAS
ERBB4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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